http://www.cincinnatichildrens.org The focus of Divisional research has been on selected psychiatric disorders. Pediatric mood disorders, which include depressive and bipolar disorders are prevalent. They seriously disrupt the lives of children and adolescents. Research in this area includes NIMH funded initiatives, along with industry supported pharmacologic trials. Current work includes investigation of longitudinal assessment of manic symptoms, the use of family-focused treatment as an adjunct to pharmacologic intervention in pediatric bipolar patients, and the efficacy of specific pharmacologic agents in the treatment of pediatric bipolar disorder. Additional work in bipolar disorders continues in conjunction with the University of Cincinnati College of Medicine Department of Psychiatry. This includes work in Neuroimaging and the study of high-risk populations.