Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood–brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the brain. This precise control of CNS homeostasis allows for proper neuronal function and also protects the neural tissue from toxins and pathogens, and alterations of these barrier properties are an important component of pathology and progression of different neurological diseases. The physiological barrier is coordinated by a series of physical, transport, and metabolic properties possessed by the endothelial cells (ECs) that form the walls of the blood vessels, and these properties are regulated by interactions with different vascular, immune, and neural cells. Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease. (See citation below) Second Channel ————————————————— ? USMLE Cases: https://www.youtube.com/channel/UCj6yv42uGIfGVI2IQqAvFNw Pocket Apps ————————————————— ? Pocket ECG https://play.google.com/store/apps/details?id=usmle.pass.basicecg ? Pocket Guidelines https://play.google.com/store/apps/details?id=com.talhahasanzia.threelevellistview ❤️ Pocket Heart Sounds https://play.google.com/store/apps/details?id=usmle.pass.heartsounds ? Pocket Lung Sounds https://play.google.com/store/apps/details?id=usmle.pass.lungsounds ? Pocket Labs https://play.google.com/store/apps/details?id=labs.reviews.labss ? Pocket Micro https://play.google.com/store/apps/details?id=com.bacterials.agarss ? Pocket OSCE https://play.google.com/store/apps/details?id=com.oscess.pess Topic References ————————————————— ?https://www.kenhub.com/en/library/anatomy/the-blood-brain-barrier ?https://qbi.uq.edu.au/brain/brain-anatomy/what-blood-brain-barrier ?https://www.frontiersin.org/articles/10.3389/fnins.2019.00521/full Description’s Citation ————————————————— Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015;7(1):a020412. Published 2015 Jan 5. doi:10.1101/cshperspect.a020412 Music Credit ————————————————— Title: Ticker by Silent Partner Title: Always Dreaming by Within Reach Title: Drift by Drift Software and Hardware ————————————————— Microphone: Blue Yeti X Professional Condenser Audio Software: Adobe Audition CC 2020 Video Software: Filmora-X and Adobe After Effects CS 6 Thumbnail Software: Adobe Photoshop CS 6 Join Us ————————————————— Instagram https://www.instagram.com/medical.pronunciations Twitter https://twitter.com/USMLEpass Whatsapp Study Group https://chat.whatsapp.com/J1QZFU5uCJAGQS8FikYzT6 Thanks for watching. You are awesome!