Structure & Function of kidney Function ————— Elimination of waste products Regulation of electrolytes and water Regulation of the acid-base physiology Regulation of blood pressure and blood volume Hormone synthesis Erythropoietin (EPO) ———————————- Secreted by peritubular interstitial cells Function: stimulates erythropoiesis in bone marrow Regulation 1.Positive feedback: anemia/blood loss, hypoxia 2.Induced by the transcription factor HIF (hypoxia-inducible factor) Calciferol: cells of the proximal convoluted tubule convert 25-OH vitamin D3 → into the active calcitriol 1,25-(OH)2 vitamin D3 Prostaglandins: maintain renal blood flow via vasodilation of afferent arterioles Dopamine: cells of the proximal convoluted tubules secrete dopamine → helps maintain renal blood flow via vasodilation of interlobular arteries, afferent arterioles, and efferent arterioles Participate in gluconeogenesis (glutamine and glutamate) and ketogenesis #structureofkidney #functionofkidney #structureandfunctionofkidney #kidney #physiologyofkidney