Lipid-lowering agents, or hypolipidemic agents, are a group of drugs that are used in the treatment of high levels of fats, such as triglycerides and cholesterol, in the blood. Hyperlipidemia (also known as high cholesterol) is the key contributing factors to the development of atherosclerosis (hardening of the arteries), which can lead to stroke and heart attack. This pharmacology lecture covers topics such as pathophysiology of hyperlipidemia; lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, and vascular inflammation; mechanism of action of lipid-lowering drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitors, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin, Niacin, Fenofibrate, Gemfibrozil, Colesevelam, Colestipol, Cholestyramine, Ezetimibe, Evolocumab, Alirocumab, Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Icosapent ethyl, and Fish oil. Thanks for watching and don’t forget to SUBSCRIBE, hit the LIKE button? and click the BELL button? for future notifications!!! Like what we do? Learn how to support us on Patreon! ?https://www.patreon.com/speedpharmacology Looking for more pharmacology knowledge? Follow us on Facebook!? https://www.facebook.com/SpeedPharmacology 0:00 Pathophysiology of hyperlipidemia 4:18 HMG-CoA reductase inhibitors – Statins 6:20 Nicotinic acid – Niacin 7:39 Fibrates 9:25 Bile acid sequestrants 10:51 Cholesterol absorption inhibitors 12:24 PCSK9 inhibitors 13:27 Omega−3 fatty acids