This is a brief video on pharmacologic agents that help reduce weight or control weight. I created this presentation with Google Slides. Image were created or taken from Wikimedia Commons I created this video with the YouTube Video Editor. ADDITIONAL TAGS: Anti-obesity medication Pharmacological agents that reduce weight or help control weight Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide By James Heilman, MD – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=4854133 Phentermine Approved by FDA in 1959 Mechanism: releases norepinephrine Short term use (3 to 6 months) Not approved for long term use Cheap Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide Orlistat Approved by FDA in 1999 Mechanism: inhibits lipase (gastric and pancreatic) Therefore, decrease in fat breakdown and absorption Side effects: GI disturbance (cramps, fecal incontinence, diarrhea (specifically steatorrhea)), fat soluble vitamin deficiency (vitamins DEAK) → give multivitamins Good for CAD patients or those at risk for CVD Available over-the-counter Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide Phentermine/topiramate Approved by FDA in 2010 Phentermine mechanism: releases norepinephrine Topiramate mechanism: blocks Na channels, modulates GABA receptor to increase action Used for migraine prophylaxis and seizures (simple, complex, tonic-clonic) Side effects: mental sedation, kidney stones Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide Lorcaserin Approved by FDA in 2012 Mechanism: agonists serotonin (5-HT2C) receptor Side effects: dizziness, dry mouth, GI disturbance (nausea, vomiting, diarrhea), fatigue, headaches Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide Bupropion/naltrexone Approved by FDA in 2014 Bupropion mechanism: increase norepinephrine and dopamine levels Naltrexone mechanism: opioid antagonist Side effects: anxiety, headaches Good for patients also struggling with smoking cessation (bupropion approved for smoking cessation) Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide Liraglutide Approved by FDA in 2015 Mechanism: agonizes the GLP-1 receptor (GLP-1 analog) Subcutaneous injection Side effects: pancreatitis, nausea, vomiting Phentermine Orlistat Phentermine/ topiramate Lorcaserin Bupropion/ naltrexone Liraglutide