ethanol extract of Reishi is a strong 5a reductase inhibitor and possible potent anti androgen http://www.sciencedirect.com/science/article/pii/S0378874105003673 “A compound in Reishi that goes by the name ganoderol B, for example, does not just have inhibitory activity against 5α-reductase, but can also bind to the androgen receptor directly (if you will you could say it acts like an anti-anabolic SARM). Now, this was good news in a study that has been conducted by Liu et al., because it inhibited androgen-induced cell growth in an LNCaP cell line while suppressing testosterone-induced regrowth of the ventral prostate in rats. If those effects are however non-selective, you are about to run into problems once the molecules bind to receptors outside the prostate — epression for example, if they block the androgen effects in the brain, etc.”http://suppversity.blogspot.com/2012/10/reishi-protects-against-cancer-contains.html http://en.wikipedia.org/wiki/Dihydrotestosterone