VANCOMYCIN Mechanism of Action Vancomycin is an antibiotic drug which is structurally classified as a glycopeptide. It mainly acts by prevention of cell-wall biosynthesis of bacteria. It is specially effective against gram-positive bacteria and has been known to be effective against resistant strains of MRSA. Vancomycin is known as the drug of last resort as it generally used when all other treatments have failed. However, bacteria have started developing resistance to vancomycin as well- leading to use of other antibiotics. Vancomycin acts by inhibiting cell wall synthesis of bacteria. Peptidoglycan layer of the cell wall is rigid due to its highly cross-linked structure. During the synthesis of the peptidoglycan layer of bacteria, new building blocks of peptidoglycan get inserted (i.e. monomers of N-acetylmuramic acid and N-acetylglucosamine) into the membrane.Vancomycin inhibit the synthesis of bacterial cell wall phospholipids as well as peptidoglycan polymerization in a time dependent fashion by binding to the D-ala-D-ala side chain of the precursor pentapeptide.This prevent the transglycosylation step in peptidoglycan polymerization . By doing so, vancomycin makes the peptidoglycan layer less rigid and more permeable. This causes cellular contents of the bacteria to leak out and eventually death of the bacteria. Mutations in the transpeptidase enzyme can lead to increased resistance to vancomycin.

VANCOMYCIN Mechanism of Action
- Post author:
- Post published:May 22, 2021
- Post category:Uncategorized
- Post comments:0 Comments
You Might Also Like

Industrial Chemicals By Krishna Antioxidants Pvt Ltd, Mumbai

How to stretch before running

DXA Scan
![Read more about the article HDL & Reverse Cholesterol Transport [HD]](https://videos.drmaheshkumar.com/wp-content/uploads/2021/05/HDL-Reverse-Cholesterol-Transport-HD-300x169.jpg)
HDL & Reverse Cholesterol Transport [HD]

Endocrinology – Overview

Impact of coronary CT angiography on planning of bifurcation PCI

Revital Multivitamins | क्या ये असरदार है ? जानिये सबकुछ | Revital usage, benefits & side effects

BMI Calculation

During Workout Nutrition Video – 1

L-Glutamine Benefits

Multivitamin For Women? Learn How Weight Loss Supplements Work

Couch Tricep Dips

Stability-Ball Back Extension – Unleash Your Hottest Body

(CC) How to Pronounce pantoprazole (Protonix) Backbuilding Pharmacology

Leg Raises-2

World’s Best Multivitamins at CHEMIST SHOP | Cheapest | Guaranteed Results

Condensation of Lipids

Bodybuilding Nutrition, Diet Recipes & Workout – 13

Barbell Wide Grip Upright Row

Working of Digestive System

Pharmacology Mechanism of ActionMOA 3D Animation Demoreel

Ideal Number Of Sets & Reps For Muscle Growth | YOU ARE DOING IT WRONG!

3 Ways to Work Your Back and Arms With the Lat Pull Machine | Fitness How To

Low Pulley Biceps Curl
Post Workout Nutrition

Abductor-1

Cellular structure of bone | Muscular-skeletal system physiology | NCLEX-RN | Khan Academy

Body Mass Index (BMI)

Do We Really Use Only 10% Of Our Brain?

A Student with Mental Illness

Diet & Rheumatoid Arthritis

Hair Transplant Complete Process 2020 3D Animation

25 Foods For Heart Disease – Foods To Help Heart Disease

Top 10 Diabetes Symptoms in Women

Community Psychology Video – 1

First Aid Video – 3

Best Vitamin B Complex Supplements – Top 10 Ranked

Sports Physiotherapy Video – 2

History Of Surgery Video – 3

Pantoprazole & Domperidone Tablets by Yagya Pharmaceutical

Top 3 Exercises to Build Rear Delts, Rhomboids, & Middle Traps
